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Non-Watson–Crick RNA synthesis suited to origin functions

A templated RNA synthesis is characterized in which G(5′)pp(5′)G accelerates synthesis of A(5′)pp(5′)A from pA and chemically activated ImpA precursors. Similar acceleration is not observable in the presence of UppU, CppC, AppG, AppA, or pG alone. Thus, it seems likely that AppA is templated by GppG...

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Bibliografiske detaljer
Udgivet i:RNA
Main Authors: Puthenvedu, Deepa, Majerfeld, Irene, Yarus, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733574/
https://ncbi.nlm.nih.gov/pubmed/29042506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.063974.117
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