Glyoxals as in vivo RNA structural probes of guanine base-pairing

Elucidation of the folded structures that RNA forms in vivo is vital to understanding its functions. Chemical reagents that modify the Watson–Crick (WC) face of unprotected nucleobases are particularly useful in structure elucidation. Dimethyl sulfate penetrates cell membranes and informs on RNA bas...

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Dettagli Bibliografici
Pubblicato in:RNA
Autori principali: Mitchell, David, Ritchey, Laura E., Park, Hongmarn, Babitzke, Paul, Assmann, Sarah M., Bevilacqua, Philip C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733565/
https://ncbi.nlm.nih.gov/pubmed/29030489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064014.117
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