Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo

[Image: see text] In an effort to find new therapeutic interventions addressing the unmet medical need of patients with idiopathic pulmonary fibrosis, we initiated a program to identify new autotaxin (ATX) inhibitors. Starting from a recently published compound (PF-8380), we identified several highl...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Kuttruff, Christian A., Ferrara, Marco, Bretschneider, Tom, Hoerer, Stefan, Handschuh, Sandra, Nosse, Bernd, Romig, Helmut, Nicklin, Paul, Roth, Gerald J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733304/
https://ncbi.nlm.nih.gov/pubmed/29259743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00312
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