Transcription Pausing Regulates Mouse Embryonic Stem Cell Differentiation

The pluripotency of embryonic stem cells (ESCs) relies on appropriate responsiveness to developmental cues. Promoter-proximal pausing of RNA polymerase II (Pol II) has been suggested to play a role in keeping genes poised for future activation. To identify the role of Pol II pausing in regulating ES...

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Bibliographic Details
Published in:Stem Cell Res
Main Authors: Tastemel, Melodi, Gogate, Aishwarya A., Malladi, Venkat S., Nguyen, Kim, Mitchell, Courtney, Banaszynski, Laura A., Bai, Xiaoying
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732849/
https://ncbi.nlm.nih.gov/pubmed/29174978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2017.11.012
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