Monocytes and granulocytes reduce CD38 expression levels on myeloma cells in patients treated with daratumumab

PURPOSE: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma (MM) cells. The aim of this study was to investigate the clinical implications and the underlying mechanisms of daratumumab-mediated CD38 reduction. EXPERIMENTAL DESIGN: We evaluated the effect of dar...

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Udgivet i:Clin Cancer Res
Main Authors: Krejcik, Jakub, Frerichs, Kris A., Nijhof, Inger S., van Kessel, Berris, van Velzen, Jeroen F., Bloem, Andries C., Broekmans, Marloes E.C., Zweegman, Sonja, van Meerloo, Johan, Musters, René J.P., Poddighe, Pino J., Groen, Richard W.J., Chiu, Christopher, Plesner, Torben, Lokhorst, Henk M., Sasser, A. Kate, Mutis, Tuna, van de Donk, Niels W.C.J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732844/
https://ncbi.nlm.nih.gov/pubmed/29025767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2027
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