Daratumumab depletes CD38(+) immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Krejcik, Jakub, Casneuf, Tineke, Nijhof, Inger S., Verbist, Bie, Bald, Jaime, Plesner, Torben, Syed, Khaja, Liu, Kevin, van de Donk, Niels W. C. J., Weiss, Brendan M., Ahmadi, Tahamtan, Lokhorst, Henk M., Mutis, Tuna, Sasser, A. Kate
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957162/
https://ncbi.nlm.nih.gov/pubmed/27222480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-687749
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