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PARP inhibition causes premature loss of cohesion in cancer cells
Poly(ADP-ribose) polymerases (PARPs) regulate various aspects of cellular function including mitotic progression. Although PARP inhibitors have been undergoing various clinical trials and the PARP1/2 inhibitor olaparib was approved as monotherapy for BRCA-mutated ovarian cancer, their mode of action...
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| Опубликовано в: : | Oncotarget |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Impact Journals LLC
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5732777/ https://ncbi.nlm.nih.gov/pubmed/29262611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21879 |
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