Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors

mTOR pathway activation and hypervascularity have been identified as important characteristics of pancreatic neuroendocrine tumors (pNETs). Agents targeting angiogenesis and mTOR, such as sunitinib and everolimus (RAD001), have been shown to result in progression-free survival of approximately 11 mo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chu, Pei-Yi, Jiang, Shih Sheng, Shan, Yan-Shen, Hung, Wen-Chun, Chen, Ming-Huang, Lin, Hui-You, Chen, Yu-Lin, Tsai, Hui-Jen, Chen, Li-Tzong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732754/
https://ncbi.nlm.nih.gov/pubmed/29262588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21665
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