Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors

mTOR pathway activation and hypervascularity have been identified as important characteristics of pancreatic neuroendocrine tumors (pNETs). Agents targeting angiogenesis and mTOR, such as sunitinib and everolimus (RAD001), have been shown to result in progression-free survival of approximately 11 mo...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Chu, Pei-Yi, Jiang, Shih Sheng, Shan, Yan-Shen, Hung, Wen-Chun, Chen, Ming-Huang, Lin, Hui-You, Chen, Yu-Lin, Tsai, Hui-Jen, Chen, Li-Tzong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732754/
https://ncbi.nlm.nih.gov/pubmed/29262588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21665
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