Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors

mTOR pathway activation and hypervascularity have been identified as important characteristics of pancreatic neuroendocrine tumors (pNETs). Agents targeting angiogenesis and mTOR, such as sunitinib and everolimus (RAD001), have been shown to result in progression-free survival of approximately 11 mo...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Chu, Pei-Yi, Jiang, Shih Sheng, Shan, Yan-Shen, Hung, Wen-Chun, Chen, Ming-Huang, Lin, Hui-You, Chen, Yu-Lin, Tsai, Hui-Jen, Chen, Li-Tzong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2017
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732754/
https://ncbi.nlm.nih.gov/pubmed/29262588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21665
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