Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming

Reprogramming of cellular identity using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, and regenerative medicine. However, generation of desired cell types using this approach is often plagued by inefficiency, slow conve...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Ruetz, Tyson, Pfisterer, Ulrich, Di Stefano, Bruno, Ashmore, James, Beniazza, Meryam, Tian, Tian V., Kaemena, Daniel F., Tosti, Luca, Tan, Wenfang, Manning, Jonathan R., Chantzoura, Eleni, Ottosson, Daniella Rylander, Collombet, Samuel, Johnsson, Anna, Cohen, Erez, Yusa, Kosuke, Linnarsson, Sten, Graf, Thomas, Parmar, Malin, Kaji, Keisuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732323/
https://ncbi.nlm.nih.gov/pubmed/29174331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.10.013
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