Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling

In this study, we investigated the mechanism by which tomentodione M (TTM), a novel natural syncarpic acid-conjugated monoterpene, reversed multi-drug resistance (MDR) in cancer cells. TTM increased the cytotoxicity of chemotherapeutic drugs such as docetaxel and doxorubicin in MCF-7/MDR and K562/MD...

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Vydáno v:Oncotarget
Hlavní autoři: Zhou, Xu-Wei, Xia, Yuan-Zheng, Zhang, Ya-Long, Luo, Jian-Guang, Han, Chao, Zhang, Hao, Zhang, Chao, Yang, Lei, Kong, Ling-Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731928/
https://ncbi.nlm.nih.gov/pubmed/29254218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21949
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