Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis

The outcome of visceral leishmaniasis, caused by parasite Leishmania donovani, depends on the recruitment of leishmanicidal Th1 cells. Chemokine receptor CXCR3, preferentially expressed by Th1 cells, is critical for migration of these T cells during infection. During chronic VL, there is a decrease...

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Udgivet i:Cell Immunol
Main Authors: Varikuti, Sanjay, Natarajan, Gayathri, Oghumu, Steve, Sperling, Rachel H., Moretti, Ellen, Stock, James, Papenfuss, Tracey L., Satoskar, Abhay R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730987/
https://ncbi.nlm.nih.gov/pubmed/27614845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2016.08.016
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