A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness

Overexpression of DNMT1 and KIT is prevalent in lung cancer, yet the underlying molecular mechanisms are poorly understood. While the deregulated activation of DNMT1 or KIT has been implicated in lung cancer pathogenesis, whether and how DNMT1 and KIT orchestrate lung tumorigenesis are unclear. Here...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Yan, Fei, Shen, Na, Pang, Jiuxia, Zhao, Na, Deng, Bo, Li, Bing, Yang, Yanan, Yang, Ping, Molina, Julian R., Liu, Shujun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730463/
https://ncbi.nlm.nih.gov/pubmed/28869603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.305
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