The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2′-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells

Lung cancer cells are sensitive to 5-aza-2′-deoxycytidine (decitabine) or midostaurin (PKC412), because decitabine restores the expression of methylation-silenced tumor suppressor genes, whereas PKC412 inhibits hyperactive kinase signaling, which is essential for cancer cell growth. Here, we demonst...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yan, Fei, Shen, Na, Pang, Jiuxia, Molina, Julian R., Yang, Ping, Liu, Shujun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513109/
https://ncbi.nlm.nih.gov/pubmed/26085088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.633693
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