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Requirement for Itk kinase activity for Th1, Th2, Th17 and iNKT cell cytokine production revealed by an allele sensitive mutant
Itk(−/−) mice exhibit defects in activation, development and function of CD4(+) and CD8(+) T cells and iNKT cells. These and other defects in these mice make it difficult to uncouple the developmental versus functional requirement of Itk signaling. Here we report an allele sensitive mutant of Itk (I...
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| Vydáno v: | Eur J Immunol |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5730406/ https://ncbi.nlm.nih.gov/pubmed/25989458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201445087 |
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