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IL-2 inducible T cell kinase (ITK) tunes T regulatory cell development and is required for suppressive function()
ITK is a key signaling mediator downstream of TcR, mediating T cell positive selection, innate T cell and CD4(+) Th2/Th17 differentiation. Here we show that ITK also negatively tunes IL-2-induced expansion of Foxp3(+) regulatory T cells (Treg). In vivo, Treg abundance is inversely correlated with IT...
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| Yayımlandı: | J Immunol |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352551/ https://ncbi.nlm.nih.gov/pubmed/25063868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400968 |
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