A multi-stage antimalarial targets the plasmepsins IX and X essential for invasion and egress

Regulated exocytosis by secretory organelles is important for malaria parasite invasion and egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are extensively proteolytically processed both pre- and post-exocytosis. Here, we report the multi-stage anti-plasmodial...

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Udgivet i:Science
Main Authors: Pino, Paco, Caldelari, Reto, Mukherjee, Budhaditya, Vahokoski, Juha, Klages, Natacha, Maco, Bohumil, Collins, Christine R., Blackman, Michael J., Kursula, Inari, Heussler, Volker, Brochet, Mathieu, Soldati-Favre, Dominique
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730047/
https://ncbi.nlm.nih.gov/pubmed/29074775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf8675
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