Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied extensively but the functions of plasmepsins IX and...

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Bibliographic Details
Published in:Science
Main Authors: Nasamu, Armiyaw S., Glushakova, Svetlana, Russo, Ilaria, Vaupel, Barbara, Oksman, Anna, Kim, Arthur S., Fremont, Daved H., Tolia, Niraj, Beck, Josh R., Meyers, Marvin J., Niles, Jacquin C., Zimmerberg, Joshua, Goldberg, Daniel E.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2017
Subjects:
Malaria
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928414/
https://ncbi.nlm.nih.gov/pubmed/29074774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan1478
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