Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro

Recently, we showed that TSH-enhanced differentiation of a human preosteoblast-like cell model involved a β-arrestin 1 (β-Arr 1)-mediated pathway. To study this pathway in more detail, we sought to discover a small molecule ligand that was functionally selective toward human TSH receptor (TSHR) acti...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Neumann, Susanne, Eliseeva, Elena, Boutin, Alisa, Barnaeva, Elena, Ferrer, Marc, Southall, Noel, Kim, David, Hu, Xin, Morgan, Sarah J., Marugan, Juan J., Gershengorn, Marvin C.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
Fag:
Drug Discovery and Translational Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729612/
https://ncbi.nlm.nih.gov/pubmed/29089368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.244095
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