Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary conservation and the many other reported binding partners suggest an additional function not directly linked to apoptosis regulation. To identify such a function, we stud...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Wali, Jibran A, Galic, Sandra, Tan, Christina YR, Gurzov, Esteban N, Frazier, Ann E, Connor, Timothy, Ge, Jingjing, Pappas, Evan G, Stroud, David, Varanasi, L Chitra, Selck, Claudia, Ryan, Michael T, Thorburn, David R, Kemp, Bruce E, Krishnamurthy, Balasubramanian, Kay, Thomas WH, McGee, Sean L, Thomas, Helen E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2018
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729528/
https://ncbi.nlm.nih.gov/pubmed/29053141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.168
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