AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

BACKGROUND: N-arachidonoylphenolamine (AM404), a paracetamol metabolite, is a potent agonist of the transient receptor potential vanilloid type 1 (TRPV1) and low-affinity ligand of the cannabinoid receptor type 1 (CB1). There is evidence that AM404 exerts its pharmacological effects in immune cells....

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Bibliografische gegevens
Gepubliceerd in:J Neuroinflammation
Hoofdauteurs: Saliba, Soraya Wilke, Marcotegui, Ariel R., Fortwängler, Ellen, Ditrich, Johannes, Perazzo, Juan Carlos, Muñoz, Eduardo, de Oliveira, Antônio Carlos Pinheiro, Fiebich, Bernd L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729401/
https://ncbi.nlm.nih.gov/pubmed/29237478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-1014-3
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