Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404

Despite the enormous disease burden associated with dengue virus infections, a licensed antiviral drug is lacking. Here, we show that the paracetamol (acetaminophen) metabolite AM404 inhibits dengue virus replication. Moreover, we find that mutations in NS4B that were previously found to confer resi...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: van Cleef, Koen W. R., Overheul, Gijs J., Thomassen, Michael C., Marjakangas, Jenni M., van Rij, Ronald P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808173/
https://ncbi.nlm.nih.gov/pubmed/26856827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02462-15
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