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AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
BACKGROUND: N-arachidonoylphenolamine (AM404), a paracetamol metabolite, is a potent agonist of the transient receptor potential vanilloid type 1 (TRPV1) and low-affinity ligand of the cannabinoid receptor type 1 (CB1). There is evidence that AM404 exerts its pharmacological effects in immune cells....
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Publicado no: | J Neuroinflammation |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729401/ https://ncbi.nlm.nih.gov/pubmed/29237478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-1014-3 |
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