Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia

Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack. Human KIR haplotypes comprise genes encoding mainly inhibitory receptors (KIR A) or activating and inh...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Bernson, E, Hallner, A, Sander, F E, Wilsson, O, Werlenius, O, Rydström, A, Kiffin, R, Brune, M, Foà, R, Aurelius, J, Martner, A, Hellstrand, K, Thorén, F B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729331/
https://ncbi.nlm.nih.gov/pubmed/28529313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.151
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