Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia

Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack. Human KIR haplotypes comprise genes encoding mainly inhibitory receptors (KIR A) or activating and inh...

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Bibliografiske detaljer
Udgivet i:Leukemia
Main Authors: Bernson, E, Hallner, A, Sander, F E, Wilsson, O, Werlenius, O, Rydström, A, Kiffin, R, Brune, M, Foà, R, Aurelius, J, Martner, A, Hellstrand, K, Thorén, F B
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729331/
https://ncbi.nlm.nih.gov/pubmed/28529313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.151
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