Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

Hematopoietic stem cell (HSC)–based gene therapy trials are now moving toward the use of lentiviral vectors (LVs) with success. However, one challenge in the field remains: efficient transduction of HSCs without compromising their stem cell potential. Here we showed that measles virus glycoprotein–d...

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Detaylı Bibliyografya
Yayımlandı:Blood Adv
Asıl Yazarlar: Lévy, Camille, Amirache, Fouzia, Girard-Gagnepain, Anais, Frecha, Cecilia, Roman-Rodríguez, Francisco J., Bernadin, Ornellie, Costa, Caroline, Nègre, Didier, Gutierrez-Guerrero, Alejandra, Vranckx, Lenard S., Clerc, Isabelle, Taylor, Naomi, Thielecke, Lars, Cornils, Kerstin, Bueren, Juan A., Rio, Paula, Gijsbers, Rik, Cosset, François-Loïc, Verhoeyen, Els
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2017
Konular:
Gene Therapy
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728281/
https://ncbi.nlm.nih.gov/pubmed/29296856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007773
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