Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

Hematopoietic stem cell (HSC)–based gene therapy trials are now moving toward the use of lentiviral vectors (LVs) with success. However, one challenge in the field remains: efficient transduction of HSCs without compromising their stem cell potential. Here we showed that measles virus glycoprotein–d...

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Publicat a:Blood Adv
Autors principals: Lévy, Camille, Amirache, Fouzia, Girard-Gagnepain, Anais, Frecha, Cecilia, Roman-Rodríguez, Francisco J., Bernadin, Ornellie, Costa, Caroline, Nègre, Didier, Gutierrez-Guerrero, Alejandra, Vranckx, Lenard S., Clerc, Isabelle, Taylor, Naomi, Thielecke, Lars, Cornils, Kerstin, Bueren, Juan A., Rio, Paula, Gijsbers, Rik, Cosset, François-Loïc, Verhoeyen, Els
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2017
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728281/
https://ncbi.nlm.nih.gov/pubmed/29296856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007773
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