Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

Hematopoietic stem cell (HSC)–based gene therapy trials are now moving toward the use of lentiviral vectors (LVs) with success. However, one challenge in the field remains: efficient transduction of HSCs without compromising their stem cell potential. Here we showed that measles virus glycoprotein–d...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Lévy, Camille, Amirache, Fouzia, Girard-Gagnepain, Anais, Frecha, Cecilia, Roman-Rodríguez, Francisco J., Bernadin, Ornellie, Costa, Caroline, Nègre, Didier, Gutierrez-Guerrero, Alejandra, Vranckx, Lenard S., Clerc, Isabelle, Taylor, Naomi, Thielecke, Lars, Cornils, Kerstin, Bueren, Juan A., Rio, Paula, Gijsbers, Rik, Cosset, François-Loïc, Verhoeyen, Els
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Gene Therapy
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728281/
https://ncbi.nlm.nih.gov/pubmed/29296856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007773
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