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Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

Hematopoietic stem cell (HSC)–based gene therapy trials are now moving toward the use of lentiviral vectors (LVs) with success. However, one challenge in the field remains: efficient transduction of HSCs without compromising their stem cell potential. Here we showed that measles virus glycoprotein–d...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Lévy, Camille, Amirache, Fouzia, Girard-Gagnepain, Anais, Frecha, Cecilia, Roman-Rodríguez, Francisco J., Bernadin, Ornellie, Costa, Caroline, Nègre, Didier, Gutierrez-Guerrero, Alejandra, Vranckx, Lenard S., Clerc, Isabelle, Taylor, Naomi, Thielecke, Lars, Cornils, Kerstin, Bueren, Juan A., Rio, Paula, Gijsbers, Rik, Cosset, François-Loïc, Verhoeyen, Els
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728281/
https://ncbi.nlm.nih.gov/pubmed/29296856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007773
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