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Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier

Decreased clearance of potentially toxic metabolites, due to aging changes, likely plays a significant role in the accumulation of amyloid-beta peptides (Aβ) and other macromolecules in the brains of the elderly and in Alzheimer’s disease (AD). Aging is the single most important risk factor for AD d...

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Bibliografische gegevens
Gepubliceerd in:Neurobiol Aging
Hoofdauteurs: Osgood, Doreen, Miller, Miles C., Messier, Arthur A., Gonzalez, Liliana, Silverberg, Gerald D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728118/
https://ncbi.nlm.nih.gov/pubmed/28654861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.05.011
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