Lipopolysaccharide Alters the Blood-brain Barrier Transport of Amyloid Beta Protein: A Mechanism for Inflammation in the Progression of Alzheimer’s Disease

Alzheimer’s disease (AD) brains are characterized by accumulation of amyloid-ß protein (Aβ) and neuroinflammation. Increased blood-to-brain influx and decreased brain-to-blood efflux across the blood-brain barrier (BBB) have been proposed as mechanisms for Aß accumulation. Epidemiological studies su...

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Detalhes bibliográficos
Main Authors: Jaeger, Laura B., Dohgu, Shinya, Sultana, R., Lynch, Jessica L., Owen, Joshua B., Erickson, Michelle A., Shah, Gul N., Price, Tulin O., Fleegal-Demotta, Melissa A., Butterfiled, D. Allan, Banks, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783557/
https://ncbi.nlm.nih.gov/pubmed/19486646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2009.01.017
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