Testing the Neurovascular Hypothesis of Alzheimer’s Disease: LRP-1 Antisense Reduces Blood-Brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

Decreased clearance is the main reason amyloid-β protein (Aβ) in increased in the brains of patients with Alzheimer’s disease (AD). The neurovascular hypothesis states that this decreased clearance is caused by impairment of low density lipoprotein receptor related protein-1 (LRP-1), the major brain...

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Detalhes bibliográficos
Main Authors: Jaeger, Laura B., Dohgu, Shinya, Hwang, Mark C., Farr, Susan A., Murphy, M. Paul, Fleegal-DeMotta, Melissa A., Lynch, Jessica L., Robinson, Sandra M., Niehoff, Michael L., Johnson, Steven N., Kumar, Vijaya B., Banks, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802833/
https://ncbi.nlm.nih.gov/pubmed/19433890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1074
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