Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

Metastasis is the main cause of death in cancer patients. TGF-β is pro-metastatic for malignant cancer cells. Here we report a loss-of-function screen in mice with metastasis as readout and identify OTUD1 as a metastasis-repressing factor. OTUD1-silenced cancer cells show mesenchymal and stem-cell-l...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Zhengkui, Fan, Yao, Xie, Feng, Zhou, Hang, Jin, Ke, Shao, Li, Shi, Wenhao, Fang, Pengfei, Yang, Bing, van Dam, Hans, ten Dijke, Peter, Zheng, Xiaofeng, Yan, Xiaohua, Jia, Junling, Zheng, Min, Jin, Jin, Ding, Chen, Ye, Sheng, Zhou, Fangfang, Zhang, Long
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727433/
https://ncbi.nlm.nih.gov/pubmed/29235476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02029-7
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