Retargeting Lentiviruses via SpyCatcher-SpyTag Chemistry for Gene Delivery into Specific Cell Types

We report a simple strategy for the creation of lentiviral vectors specific to any desired target cells. SpyTag is inserted into an engineered Sindbis virus envelope protein and displayed on the lentivirus surface to create Sindbis virus-SpyTag pseudoparticles (Sind-SpyTag-pp). The SpyTag serves as...

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Bibliographic Details
Published in:mBio
Main Authors: Kasaraneni, Nagarjun, Chamoun-Emanuelli, Ana M., Wright, Gus, Chen, Zhilei
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727413/
https://ncbi.nlm.nih.gov/pubmed/29233896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01860-17
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