A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

Histidine kinases are key regulators in the bacterial two-component systems that mediate the cellular response to environmental changes. The vast majority of the sensor histidine kinases belong to the bifunctional HisKA family, displaying both kinase and phosphatase activities toward their substrate...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Liu, Yixiang, Rose, Joshua, Huang, Shaojia, Hu, Yangbo, Wu, Qiong, Wang, Dan, Li, Conggang, Liu, Maili, Zhou, Pei, Jiang, Ling
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727384/
https://ncbi.nlm.nih.gov/pubmed/29235472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02310-9
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