A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

Histidine kinases are key regulators in the bacterial two-component systems that mediate the cellular response to environmental changes. The vast majority of the sensor histidine kinases belong to the bifunctional HisKA family, displaying both kinase and phosphatase activities toward their substrate...

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Udgivet i:Nat Commun
Main Authors: Liu, Yixiang, Rose, Joshua, Huang, Shaojia, Hu, Yangbo, Wu, Qiong, Wang, Dan, Li, Conggang, Liu, Maili, Zhou, Pei, Jiang, Ling
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727384/
https://ncbi.nlm.nih.gov/pubmed/29235472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02310-9
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