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Assembly and architecture of the Wnt/β‐catenin signalosome at the membrane
Wnt/β‐catenin signalling is initiated by a ternary Wnt‐Frizzled (FZD)‐LDL receptor‐related protein (LRP) 5/6 binding event. The resulting conformational changes in the FZD and LRP5/6 receptors promote the assembly of an intracellular signalosome driven by Dishevelled and Axin co‐polymerization. Rece...
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| Pubblicato in: | Br J Pharmacol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727340/ https://ncbi.nlm.nih.gov/pubmed/28941231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14048 |
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