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A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants
Superoxide dismutase 1 (SOD1) is an important metalloprotein for cellular oxidative stress defence, that is mutated in familiar variants of Amyotrophic Lateral Sclerosis (fALS). Some mutations destabilize the apo protein, leading to the formation of misfolded, toxic species. The Copper Chaperone for...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727297/ https://ncbi.nlm.nih.gov/pubmed/29234142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17815-y |
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