Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the consensus Ψ-K-x-E/D sumoylation motif. We have previously shown that acetylation of the SUMO E2 conjugase enzyme, Ubc9, at K65 downregulates its binding to the NDSM...

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Pubblicato in:Sci Rep
Autori principali: Naik, Mandar T., Kang, Mooseok, Ho, Chun-Chen, Liao, Pei-Hsin, Hsieh, Yung-Lin, Naik, Nandita M., Wang, Szu-Huan, Chang, Iksoo, Shih, Hsiu-Ming, Huang, Tai-Huang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727262/
https://ncbi.nlm.nih.gov/pubmed/29234076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17465-0
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