Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Smad transcription factors activated by TGF-β or by BMP receptors form trimeric complexes with Smad4 to target specific genes for cell fate regulation. The CAGAC motif has been considered as the main binding element for Smad2/3/4, whereas Smad1/5/8 have been thought to preferentially bind GC-rich el...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Martin-Malpartida, Pau, Batet, Marta, Kaczmarska, Zuzanna, Freier, Regina, Gomes, Tiago, Aragón, Eric, Zou, Yilong, Wang, Qiong, Xi, Qiaoran, Ruiz, Lidia, Vea, Angela, Márquez, José A., Massagué, Joan, Macias, Maria J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727232/
https://ncbi.nlm.nih.gov/pubmed/29234012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02054-6
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