The AP-1 transcription factor JunB is required for Th17 cell differentiation

Interleukin (IL)-17-producing T helper (Th17) cells are crucial for host defense against extracellular microbes and pathogenesis of autoimmune diseases. Here we show that the AP-1 transcription factor JunB is required for Th17 cell development. Junb-deficient CD4(+) T cells are able to develop in vi...

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Published in:Sci Rep
Main Authors: Yamazaki, Soh, Tanaka, Yoshihiko, Araki, Hiromitsu, Kohda, Akira, Sanematsu, Fumiyuki, Arasaki, Tomoko, Duan, Xuefeng, Miura, Fumihito, Katagiri, Takaharu, Shindo, Ryodai, Nakano, Hiroyasu, Ito, Takashi, Fukui, Yoshinori, Endo, Shogo, Sumimoto, Hideki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727176/
https://ncbi.nlm.nih.gov/pubmed/29234109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17597-3
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