Mechanisms of μ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord

The interaction between NMDA receptors and μ-opioid receptors in primary afferent terminals was studied by using NMDA to induce substance P release, measured as neurokinin 1 receptor internalization. In rat spinal cord slices, the μ-opioid receptor agonists morphine, DAMGO and endomorphin-2 inhibite...

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Publicado en:Neuropharmacology
Main Authors: Chen, Wenling, Ennes, Helena S., McRoberts, James A., Marvizon, Juan Carlos
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726399/
https://ncbi.nlm.nih.gov/pubmed/29042318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.10.014
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