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Nascent peptide assists the ribosome in recognizing chemically distinct small molecules

Regulation of gene expression in response to the changing environment is critical for cell survival. For instance, binding of macrolide antibiotics to the ribosome promote the translation arrest at the leader ORFs ermCL and ermBL necessary for inducing antibiotic resistance genes ermC and ermB. Clad...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Gupta, Pulkit, Liu, Bo, Klepacki, Dorota, Gupta, Vrinda, Schulten, Klaus, Mankin, Alexander S., Vázquez-Laslop, Nora
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726394/
https://ncbi.nlm.nih.gov/pubmed/26727240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1998
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