Novel Small Molecule Inhibitors of Protein Kinase D Suppress NF-kappaB Activation and Attenuate the Severity of Rat Cerulein Pancreatitis

Nuclear factor-kappa B (NF-κB) activation is a key early signal regulating inflammatory and cell death responses in acute pancreatitis. Our previous in vitro studies with molecular approaches on AR42J cell showed that protein kinase D (PKD/PKD1) activation was required in NF-κB activation induced by...

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Bibliographische Detailangaben
Veröffentlicht in:Front Physiol
Hauptverfasser: Yuan, Jingzhen, Tan, Tanya, Geng, Meng, Tan, Grace, Chheda, Chintan, Pandol, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725929/
https://ncbi.nlm.nih.gov/pubmed/29270134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.01014
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