Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer

BACKGROUND: Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is catalyzed by 15-lipoxygenase (15-LOX), and it has recently been reported to exhibit...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Zong, Liang, Chen, Ke, Jiang, Zhengdong, Chen, Xin, Sun, Liankang, Ma, Jiguang, Zhou, Cancan, Xu, Qinhong, Duan, Wanxing, Han, Liang, Lei, Jianjun, Li, Xuqi, Ma, Qingyong, Wang, Zheng
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725800/
https://ncbi.nlm.nih.gov/pubmed/29228980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0655-5
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