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Extending the MR‐Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy

Methods have been developed for Mendelian randomization that can obtain consistent causal estimates while relaxing the instrumental variable assumptions. These include multivariable Mendelian randomization, in which a genetic variant may be associated with multiple risk factors so long as any associ...

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Vydáno v:Stat Med
Hlavní autoři: Rees, Jessica M. B., Wood, Angela M., Burgess, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725762/
https://ncbi.nlm.nih.gov/pubmed/28960498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7492
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