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Pleiotropy robust methods for multivariable Mendelian randomization

Mendelian randomization is a powerful tool for inferring the presence, or otherwise, of causal effects from observational data. However, the nature of genetic variants is such that pleiotropy remains a barrier to valid causal effect estimation. There are many options in the literature for pleiotropy...

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Bibliographic Details
Published in:Stat Med
Main Authors: Grant, Andrew J., Burgess, Stephen
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612169/
https://ncbi.nlm.nih.gov/pubmed/34342032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.9156
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