Structure–Activity Studies of N‐Butyl‐1‐deoxynojirimycin (NB‐DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2

Analogues of N‐butyl‐1‐deoxynojirimycin (NB‐DNJ) were prepared and assayed for inhibition of ceramide‐specific glucosyltransferase (CGT), non‐lysosomal β‐glucosidase 2 (GBA2) and the lysosomal β‐glucosidase 1 (GBA1). Compounds 5 a–6 f, which carry sterically demanding nitrogen substituents, and comp...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Gu, Xingxian, Gupta, Vijayalaxmi, Yang, Yan, Zhu, Jin‐Yi, Carlson, Erick J., Kingsley, Carolyn, Tash, Joseph S., Schönbrunn, Ernst, Hawkinson, Jon, Georg, Gunda I.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725710/
https://ncbi.nlm.nih.gov/pubmed/28975712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700558
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