Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) caused by mutations in the CLN3 gene is the most prevalent inherited neurodegenerative disease in childhood resulting in widespread central nervous system dysfunction and premature death. The consequences of CLN3 mutation on the progre...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Grünewald, Benedikt, Lange, Maren D, Werner, Christian, O'Leary, Aet, Weishaupt, Andreas, Popp, Sandy, Pearce, David A, Wiendl, Heinz, Reif, Andreas, Pape, Hans C, Toyka, Klaus V, Sommer, Claudia, Geis, Christian
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Neuroscience
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724993/
https://ncbi.nlm.nih.gov/pubmed/29135436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28685
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