Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) caused by mutations in the CLN3 gene is the most prevalent inherited neurodegenerative disease in childhood resulting in widespread central nervous system dysfunction and premature death. The consequences of CLN3 mutation on the progre...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Grünewald, Benedikt, Lange, Maren D, Werner, Christian, O'Leary, Aet, Weishaupt, Andreas, Popp, Sandy, Pearce, David A, Wiendl, Heinz, Reif, Andreas, Pape, Hans C, Toyka, Klaus V, Sommer, Claudia, Geis, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724993/
https://ncbi.nlm.nih.gov/pubmed/29135436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28685
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