Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) caused by mutations in the CLN3 gene is the most prevalent inherited neurodegenerative disease in childhood resulting in widespread central nervous system dysfunction and premature death. The consequences of CLN3 mutation on the progre...

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Foilsithe in:eLife
Main Authors: Grünewald, Benedikt, Lange, Maren D, Werner, Christian, O'Leary, Aet, Weishaupt, Andreas, Popp, Sandy, Pearce, David A, Wiendl, Heinz, Reif, Andreas, Pape, Hans C, Toyka, Klaus V, Sommer, Claudia, Geis, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2017
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724993/
https://ncbi.nlm.nih.gov/pubmed/29135436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28685
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