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Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity

Increasing evidence suggests a crucial role of inflammation in cytokine-mediated β-cell dysfunction and death in type 1 diabetes mellitus, although the mechanisms are incompletely understood. Sphingosine 1-phosphate (S1P) is a multifunctional bioactive sphingolipid involved in the development of man...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Hahn, Claudine, Tyka, Karolina, Saba, Julie D., Lenzen, Sigurd, Gurgul-Convey, Ewa
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724014/
https://ncbi.nlm.nih.gov/pubmed/29070677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814491
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