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Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity
Increasing evidence suggests a crucial role of inflammation in cytokine-mediated β-cell dysfunction and death in type 1 diabetes mellitus, although the mechanisms are incompletely understood. Sphingosine 1-phosphate (S1P) is a multifunctional bioactive sphingolipid involved in the development of man...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5724014/ https://ncbi.nlm.nih.gov/pubmed/29070677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814491 |
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