Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness

Impaired mitochondrial oxidative phosphorylation (OXPHOS) capacity, accompanied by enhanced glycolysis, is a key metabolic feature of cancer cells, but its underlying mechanism remains unclear. Previously, we reported that human hepatoma cells that harbor OXPHOS defects exhibit high tumor cell invas...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Lee, Young-Kyoung, Lim, Jin J., Jeoun, Un-woo, Min, Seongki, Lee, Eun-beom, Kwon, So Mee, Lee, Changhan, Yoon, Gyesoon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724007/
https://ncbi.nlm.nih.gov/pubmed/28978646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809012
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