Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness

Impaired mitochondrial oxidative phosphorylation (OXPHOS) capacity, accompanied by enhanced glycolysis, is a key metabolic feature of cancer cells, but its underlying mechanism remains unclear. Previously, we reported that human hepatoma cells that harbor OXPHOS defects exhibit high tumor cell invas...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Lee, Young-Kyoung, Lim, Jin J., Jeoun, Un-woo, Min, Seongki, Lee, Eun-beom, Kwon, So Mee, Lee, Changhan, Yoon, Gyesoon
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724007/
https://ncbi.nlm.nih.gov/pubmed/28978646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809012
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