Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)–PDH kinase axis

Aerobic glycolysis and mitochondrial dysfunction are key metabolic features of cancer cells, but their interplay during cancer development remains unclear. We previously reported that human hepatoma cells with mitochondrial defects exhibit down-regulated lactate dehydrogenase subunit B (LDHB) expres...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Hong, Sun Mi, Lee, Young-Kyoung, Park, Imkyong, Kwon, So Mee, Min, Seongki, Yoon, Gyesoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514637/
https://ncbi.nlm.nih.gov/pubmed/30923124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006095
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